Image tag completion by local learning

The problem of tag completion is to learn the missing tags of an image. In this paper, we propose to learn a tag scoring vector for each image by local linear learning. A local linear function is used in the neighborhood of each image to predict the tag scoring vectors of its neighboring images. We construct a unified objective function for the learning of both tag scoring vectors and local linear function parame- ters. In the objective, we impose the learned tag scoring vectors to be consistent with the known associations to the tags of each image, and also minimize the prediction error of each local linear function, while reducing the complexity of each local function. The objective function is optimized by an alternate optimization strategy and gradient descent methods in an iterative algorithm. We compare the proposed algorithm against different state-of-the-art tag completion methods, and the results show its advantages

The autophagic paradox in cancer therapy

Autophagy, hallmarked by the formation of double-membrane bound organelles known as autophagosomes, is a lysosome-dependent pathway for protein degradation. The role of autophagy in carcinogenesis is context dependent. As a tumor-suppressing mechanism in early-stage carcinogenesis, autophagy inhibits inflammation and promotes genomic stability. Moreover, disruption of autophagy-related genes accelerates tumorigenesis in animals. However, autophagy may also act as a pro-survival mechanism to protect cancer cells from various forms of cellular stress. In cancer therapy, adaptive autophagy in cancer cells sustains tumor growth and survival in face of the toxicity of cancer therapy. To this end, inhibition of autophagy may sensitize cancer cells to chemotherapeutic agents and ionizing radiation. Nevertheless, in certain circumstances, autophagy mediates the therapeutic effects of some anticancer agents. Data from recent studies are beginning to unveil the apparently paradoxical nature of autophagy as a cell-fate decision machinery. Taken together, modulation of autophagy is a novel approach for enhancing the efficacy of existing cancer therapy, but its Janus-faced nature may complicate the clinical development of autophagy modulators as anticancer therapeutics

Incidence and phenotype of inflammatory bowel disease based on results from the Asia-Pacific Crohn's and colitis epidemiology study

10.1053/j.gastro.2013.04.007Gastroenterology1451158-165GAST